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Article

The epigenetic and transcriptional landscape of neuroendocrine prostate cancer

6 Dec 2019

Abstract excerpt

Tumours adapt to increasingly potent targeted therapies by transitioning to alternative lineage states. In prostate cancer, the widespread clinical application of androgen receptor (AR) pathway inhibitors has led to the insurgence of tumours relapsing with a neuroendocrine phenotype, termed neuroendocrine prostate cancer (NEPC). Recent evidence suggests that this lineage reprogramming is driven largely by...

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PMID: 31804971
DOI: 10.1530/erc-19-0420

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