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Article

RNF213 loss-of-function promotes pathological angiogenesis in moyamoya disease via the Hippo pathway.

Brain : a journal of neurology - 2 Nov 2023

Ye Fei, Niu Xingyang, Liang Feng, Dai Yuanyuan, Liang Jie, Li Jiaoxing, Wu Xiaoxin, Zheng Hanyue, Qi Tiewei, Sheng Wenli

Abstract excerpt

Moyamoya disease is an uncommon cerebrovascular disorder characterized by steno-occlusive changes in the circle of Willis and abnormal vascular network development. Ring finger protein 213 (RNF213) has been identified as an important susceptibility gene for Asian patients, but researchers have not completely elucidated whether RNF213 mutations affect the pathogenesis of moyamoya disease. Using donor superficial...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37399508
DOI: 10.1093/brain/awad225
PMCID: PMC10629795

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