Back to search

Article

Organoid Modeling and Single-Cell Profiling Uncover the Migration Mechanism of Smooth Muscle Cells in Moyamoya Disease

2024-09-03

Abstract excerpt

<h4>Summary</h4> Moyamoya disease (MMD) is a chronic cerebrovascular disorder characterized by progressive occlusion of the intracranial arteries, resulting in severe ischemic or hemorrhagic stroke. The main characteristic of the affected vessels in MMD is arterial intimal thickening. However, there are no in vitro or in vivo models that can mimic its vascular characteristics. Moreover, the mechanisms underlying...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
45cec1e1-f515-513c-a04f-b5f6ace653c1
DOI
10.1101/2024.09.01.610617
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Organoid Modeling and Single-Cell Profiling Uncover the Migration Mechanism of Smooth Muscle Cells in Moyamoya DiseaseDOI 10.1101/2024.09.01.610617
Vascular Smooth Muscle Cell Derived from IPS Cell of Moyamoya Disease - Comparative Characterization with Endothelial Cell Transcriptome.Semantic proximity
Smooth-muscle progenitor cells isolated from patients with moyamoya disease: novel experimental cell model.Semantic proximity
RNF213 deficiency in human iPSC-derived vascular organoids captures key feature of moyamoya disease vasculopathy.Semantic proximity
Cellular Functions and Gene and Protein Expression Profiles in Endothelial Cells Derived from Moyamoya Disease-Specific iPS CellsSemantic proximity
Harnessing iPSCs, 3D organoids, and multiomics to model rare vascular diseases: Emerging new approach methodologies.Semantic proximity
Identification of the potential role of S1PR1 in adult moyamoya disease based on multiple bioinformatics analysis and experimental verificationSemantic proximity
Spatial Multi-Omics Reveals Extracellular Matrix Remodeling and VSMC Phenotypic Switching in Moyamoya DiseaseSemantic proximity
Xenium In Situ Profiling Uncovers HSPG-Dependent SULF1/VEGFR2 Signaling Mediating Vascular Remodeling in Moyamoya DiseaseSemantic proximity
Single‐Cell Transcriptome Profiling Reveals Dynamic Cell Populations and Immune Infiltration in Moyamoya DiseaseSemantic proximity
Single-cell sequencing reveals that endothelial cells, EndMT cells and mural cells contribute to the pathogenesis of cavernous malformations.Semantic proximity
Cellular and Molecular Characterization of CADASIL Using In Vitro Models of Vascular Smooth Muscle Cells and Blood Vessel OrganoidsSemantic proximity
Applications, challenges, and prospects of induced pluripotent stem cells for vascular diseaseSemantic proximity
Select a neighboring publication to make it the new centre.