Article

RNF213 loss of function reshapes vascular transcriptome and spliceosome leading to disrupted angiogenesis and aggravated vascular inflammatory responses

2022-01-20

Abstract excerpt

<h4>Rationale</h4> Moyamoya disease (MMD) is a rare cerebrovascular occlusive disease that affects Asian population more often. The pathogenesis of MMD is related to mutation in RNF213 gene. However, why, and how RNF213 mutation leads to MMD is still not fully understood. <h4>Objective</h4> Analyze the impact of RNF213 loss of function on vascular cells and the observed changes correlate with MMD. <h4>Methods an...

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Literature Corpus work: 190cce50-0b9f-5b97-8275-8b54df45ee2d
DOI: 10.1101/2022.01.18.476838

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