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Article

RNF213 deficiency in human iPSC-derived vascular organoids captures key feature of moyamoya disease vasculopathy.

Microvascular research - 1 Sept 2026

Wu Mingxing, Li Sen, Liu Wei, Guo Zhaoheng, Guo Zhiying, Zhang Dong

Abstract excerpt

OBJECTIVES: This study aimed to establish a human iPSC-derived model of Moyamoya disease (MMD) by generating RNF213-knockdown vascular organoids to capture key disease-relevant vascular features. METHODS: RNF213-knockdown iPSC lines were established using lentiviral shRNA and selected with puromycin. Knockdown efficiency was validated by qRT-PCR and Western blot. Vascular organoids were differentiated from the...

Topics

Humans
Moyamoya Disease
Induced Pluripotent Stem Cells
Ubiquitin-Protein Ligases
Organoids
Adenosine Triphosphatases
Phenotype
Platelet Endothelial Cell Adhesion Molecule-1
Cell Differentiation
Neovascularization, Physiologic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Angiogenesis

Endothelial Cells

Angiogenic Proteins

Transcriptome

RNA Interference

Source

Identifiers

PMID: 42289232
DOI: 10.1016/j.mvr.2026.104979

Genes

RNF213
MMD
CCL5
COL4A1
EREG
TNMD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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