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Article

Spatially Distinct Macrophage Subsets Drive Myofibroblast Heterogeneity and Maladaptive Fibrosis in Lupus Nephritis

2026-04-30

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Objectives</h4> Lupus nephritis (LN) is a severe complication of systemic lupus erythematosus (SLE), leading to progressive renal fibrosis and functional decline. Understanding the interplay between immune cells and stromal cells is needed to develop effective therapeutic strategies. Here, we investigated the landscape of macrophage-fibroblast interactions in human LN and validated these fi...

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Literature Corpus work
4bd2997d-8340-58ec-96e3-cc423d4ba3d6
DOI
10.64898/2026.04.27.719870
Open publication

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Spatially Distinct Macrophage Subsets Drive Myofibroblast Heterogeneity and Maladaptive Fibrosis in Lupus NephritisDOI 10.64898/2026.04.27.719870
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