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Article

Macrophage heterogeneity governs the balance between fibrosis and tissue protection in systemic sclerosis.

Clinical and experimental rheumatology - 1 Aug 2026

Zheng Peimin, Liu Chaofan, Zhou Xing, Lu Jinghao, Li Ming, Zhu Lubing

Abstract excerpt

Systemic sclerosis (SSc), especially its life-threatening interstitial lung disease (SSc-ILD), urgently requires targeted therapies. This review highlights how macrophage heterogeneity, transcending the obsolete M1/M2 paradigm, acts as a central orchestrator of the pathogenic "fibro-immune axis" linking vascular injury, immune dysregulation, and fibroblast-mediated fibrosis. Single-cell RNA sequencing and spatial...

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Topics

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Share to Fibroblasts
Share to Fibrosis
Share to Lung Diseases, Interstitial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Macrophages

Share to Phenotype

Share to Scleroderma, Systemic

Share to Signal Transduction

Source

Identifiers

PMID: 42024552
DOI: 10.55563/clinexprheumatol/kfkfod

Genes

SPP1
ARG1
CCL2
FCGR3A
TREM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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