Article

Profiling Fibrosis through Single-Cell and Spatial Transcriptomics Analysis: cell identity and tissue architecture

2025-07-14

Abstract excerpt

Fibrosis, characterized by the excessive accumulation of structural and matricellular proteins in the extracellular matrix (ECM), contributes to tissue dysfunction in various chronic diseases. A central therapeutic challenge lies in identifying and targeting specific molecular drivers of fibrosis while preserving essential wound-healing functions, thereby halting or reversing disease progression. Recent single-cel...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: eaa2119b-a1f0-5d21-b274-ec470a69d4c5
DOI: 10.22541/au.175246563.34040946/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Profiling Fibrosis through Single-Cell and Spatial Transcriptomics Analysis: cell identity and tissue architectureDOI 10.22541/au.175246563.34040946/v1Read

Shared and organ-specific gene expression programs of fibrotic diseasesSemantic proximity Read

Adult fibroblasts retain organ-specific transcriptomic identitySemantic proximity Read

A bird’s eye view of fibroblast heterogeneity: A pan‐disease, pan‐cancer perspectiveSemantic proximity Read

Dissecting Fibroblast Heterogeneity in Health and Fibrotic Disease.Semantic proximity Read

Spatial genomics: Mapping the landscape of fibrosisSemantic proximity Read

Tissue-resident mesenchymal stromal cells: Implications for tissue-specific antifibrotic therapiesSemantic proximity Read

Identifying Key Cells for Fibrosis by Systematically Calling Cell Type–Phenotype Associations across Massive Heterogenous DatasetsSemantic proximity Read

Single-cell RNA sequencing reveals profibrotic roles of distinct epithelial and mesenchymal lineages in pulmonary fibrosisSemantic proximity Read

Cross-tissue single-cell transcriptomics reveals organizing principles of fibroblasts in health and diseaseSemantic proximity Read

Extracellular matrix as a driver of progressive fibrosisSemantic proximity Read

Genomics of Human Fibrotic Diseases: Disordered Wound Healing ResponseSemantic proximity Read

Single-cell RNA-sequencing reveals profibrotic roles of distinct epithelial and mesenchymal lineages in pulmonary fibrosisSemantic proximity Read