Article

Increased mitochondrial transcription initiation does not promote oxidative phosphorylation

2024-01-11

Abstract excerpt

POLRMT is the sole RNA polymerase in human mitochondria where it generates primers for mitochondrial DNA (mtDNA) replication and transcribes the mitochondrial genome to express genes encoding essential components of the oxidative phosphorylation (OXPHOS) system. Elevated POLRMT levels are found in several cancers and in mouse models with severe mitochondrial dysfunction. Here, we generated and characterized mice o...

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Literature Corpus work: 4bc68e5e-5fd4-5b5c-b5bf-641a15a7d141
DOI: 10.1101/2024.01.11.575236

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