MTERF3 Regulates Mitochondrial Ribosome Biogenesis in Invertebrates and Mammals

Abstract excerpt

Regulation of mitochondrial DNA (mtDNA) expression is critical for the control of oxidative phosphorylation in response to physiological demand, and this regulation is often impaired in disease and aging. We have previously shown that mitochondrial transcription termination factor 3 (MTERF3) is a key regulator that represses mtDNA transcription in the mouse, but its molecular mode of action has remained elusive....

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Adipose Tissue and Metabolism
• Share to ATP Synthase and ATPases Research
• Share to Mitochondrial Function and Pathology