Article
[Transcription and its regulation in mammalian and human mitochondria].
Molekuliarnaia biologiia - 1 Jan 2000
Sologub M Iu, Kochetkov S N, Temiakov D E
Abstract excerpt
In eukaryotic cells mitochondria are the primary source of ATP, which is generated by oxidative phosphorylation. In humans and mammals these organelles contain their own maternally-inherited genome. Defects in mitochondrial gene expression result in a number of human diseases and contribute to aging. Transcription of mitochondrial genes is carried out by unique transcription machinery comprised of a single...
Topics
- Aging
- Animals
- DNA Replication
- DNA, Mitochondrial
- DNA-Directed RNA Polymerases
- Gene Expression Regulation
- Genes, Mitochondrial
- Humans
- Mitochondria
- Mitochondrial Proteins
- Mutation