Article
MTERF3 is a negative regulator of mammalian mtDNA transcription.
Cell - 27 Jul 2007
Park Chan Bae, Asin-Cayuela Jorge, Cámara Yolanda, Shi Yonghong, Pellegrini Mina, Gaspari Martina, Wibom Rolf, Hultenby Kjell, Erdjument-Bromage Hediye, Tempst Paul, Falkenberg Maria, Gustafsson Claes M, Larsson Nils-Göran
Abstract excerpt
Regulation of mammalian mtDNA gene expression is critical for altering oxidative phosphorylation capacity in response to physiological demands and disease processes. The basal machinery for initiation of mtDNA transcription has been molecularly defined, but the mechanisms regulating its activity are poorly understood. In this study, we show that MTERF3 is a negative regulator of mtDNA transcription initiation....
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