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Genetic analysis of alcohol use disorder: GWAS of alcohol use disorders identification test (AUDIT) and polygenic risk scores in an east slavic population.

Drug and alcohol dependence - 1 Aug 2025

Trofimov Michil, Kudriavskii Viacheslav, Shaheen Layal, Kovalenko Elena, Vergasova Kate, Kamelin Alexey, Rubinova Valerya, Kharitonov Dmitry, Kim Anna, Plotnikov Nikolay, Elmuratov Artem, Gainetdinov Raul R, Levchenko Anastasia, Krupitsky Evgeny, Kibitov Alexander, Ilinskaya Anna, Ilinsky Valery, Rakitko Alexander

Abstract excerpt

BACKGROUND: Alcohol use disorder (AUD) significantly affects over 200 health conditions, causing about 3 million deaths annually worldwide and is approximately 50 % heritable. METHODS: We conducted a genome-wide association study (GWAS) on self-reported alcohol consumption and alcohol-related challenges (AUDIT score) in a large East Slavs cohort (N = 41,575). Genetic correlations with diverse phenotypes were...

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Identifiers

PMID: 40440926
DOI: 10.1016/j.drugalcdep.2025.112713

Genes

DLGAP2
OCA2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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