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Article

Predicting treatment-seeking status for alcohol use disorder using polygenic scores and machine learning in a deeply-phenotyped sample.

Drug and alcohol dependence - 1 Sept 2025

Jinwala Zeal, Green ReJoyce, Khan Yousef, Gelernter Joel, Kember Rachel L, Hartwell Emily E

Abstract excerpt

BACKGROUND: Few individuals with alcohol use disorder (AUD) receive treatment. Previous studies have shown drinking behavior, psychological problems, and substance dependence to predict treatment seeking. However, to date, no studies have incorporated polygenic scores (PGS), a measure of genetic risk for AUD. METHODS: In a deeply-phenotyped sample, we identified 9103 individuals diagnosed with DSM-IV AUD and...

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Identifiers

PMID: 40695097
DOI: 10.1016/j.drugalcdep.2025.112797
PMCID: PMC12447308

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