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Gene-based polygenic risk scores analysis of alcohol use disorder in African Americans

5 Jul 2022

Abstract excerpt

Abstract Genome-wide association studies (GWAS) in admixed populations such as African Americans (AA) have limited sample sizes, resulting in poor performance of polygenic risk scores (PRS). Based on the observations that many disease-causing genes are shared between AA and European ancestry (EA) populations, and some disease-causing variants are located within the boundaries of these genes, we proposed a novel...

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Alcohol Consumption and Health Effects
Genetic Associations and Epidemiology
Liver Disease Diagnosis and Treatment

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 35790736
DOI: 10.1038/s41398-022-02029-2

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