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Article

Human leukocyte antigen class II gene diversity tunes antibody repertoires to common pathogens.

Frontiers in immunology - 1 Jan 2022

Khan Taushif, Rahman Mahbuba, Ahmed Ikhlak, Al Ali Fatima, Jithesh Puthen Veettil, Marr Nico

Abstract excerpt

Allelic diversity of human leukocyte antigen (HLA) class II genes may help maintain humoral immunity against infectious diseases. In this study, we investigated germline genetic variation in classical HLA class II genes and employed a systematic, unbiased approach to explore the relative contribution of this genetic variation in the antibody repertoire to various common pathogens. We leveraged a well-defined...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 36003377
DOI: 10.3389/fimmu.2022.856497
PMCID: PMC9393332

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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