Article

Direct Read and Quantify Damage Nucleotide from an Oligonucleotide Using a Single Molecule Interface

2019-11-20

Abstract excerpt

DNA lesion such as metholcytosine( m C), 8-OXO-guanine( O G), inosine(I) etc could cause the genetic diseases. Identification of the varieties of lesion bases are usually beyond the capability of conventional DNA sequencing which is mainly designed to discriminate four bases only. Therefore, lesion detection remain challenge due to the massive varieties and less distinguishable readouts for minor structura...

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Literature Corpus work: 4b7cef9f-e114-59ff-9f00-86a0530e4cb6
DOI: 10.26434/chemrxiv.10080638.v2

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