Article
One-by-one single-molecule detection of mutated nucleobases by monitoring tunneling current using a DNA tip.
Chemical communications (Cambridge, England) - 31 Jan 2015
Bui Phuc Tan, Nishino Tomoaki, Shiigi Hiroshi, Nagaoka Tsutomu
Abstract excerpt
A DNA molecule was utilized as a probe tip to achieve single-molecule genetic diagnoses. Hybridization of the probe and target DNAs resulted in electron tunneling along the emergent double-stranded DNA. Simple stationary monitoring of the tunneling current leads to single-molecule DNA detection and discovery of base mismatches and methylation.
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