Article
Single Locked Nucleic Acid-Enhanced Nanopore Genetic Discrimination of Pathogenic Serotypes and Cancer Driver Mutations.
ACS nano - 22 May 2018
Tian Kai, Chen Xiaowei, Luan Binquan, Singh Prashant, Yang Zhiyu, Gates Kent S, Lin Mengshi, Mustapha Azlin, Gu Li-Qun
Abstract excerpt
Accurate and rapid detection of single-nucleotide polymorphism (SNP) in pathogenic mutants is crucial for many fields such as food safety regulation and disease diagnostics. Current detection methods involve laborious sample preparations and expensive characterizations. Here, we investigated a single locked nucleic acid (LNA) approach, facilitated by a nanopore single-molecule sensor, to accurately determine SNPs...
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