Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sequence-specific detection of individual DNA strands using engineered nanopores.

Nature biotechnology - 1 Jul 2001

Howorka S, Cheley S, Bayley H

Abstract excerpt

We describe biosensor elements that are capable of identifying individual DNA strands with single-base resolution. Each biosensor element consists of an individual DNA oligonucleotide covalently attached within the lumen of the alpha-hemolysin (alphaHL) pore to form a "DNA-nanopore". The binding of single-stranded DNA (ssDNA) molecules to the tethered DNA strand causes changes in the ionic current flowing through...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Pair Mismatch
Share to Biosensing Techniques
Share to Biotechnology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lipid Bilayers

Share to Nevirapine

Share to Reverse Transcriptase Inhibitors

Share to RNA-Directed DNA Polymerase

Source

Identifiers

PMID: 11433274
DOI: 10.1038/90236

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sequence-specific detection of individual DNA strands using engineered nanopores.PMID 11433274Read ↗

Chemically labeled nucleotides and oligonucleotides encode DNA for sensing with nanopores.Semantic proximity Read ↗

Direct Read and Quantify Damage Nucleotide from an Oligonucleotide Using a Single Molecule InterfaceSemantic proximity Read ↗

DNA nanotechnology assisted nanopore-based analysisSemantic proximity Read ↗

Nanopore-Based Strategy for Single-Nucleotide Mutation Detection in Sickle Cell Disease Using Anthracycline Probes.Semantic proximity Read ↗

DNA diagnostics: nanotechnology-enhanced electrochemical detection of nucleic acids.Semantic proximity Read ↗

Nucleotide discrimination with DNA immobilized in the MspA nanopore.Semantic proximity Read ↗

Rapid and label-free single-nucleotide discrimination via an integrative nanoparticle-nanopore approach.Semantic proximity Read ↗

Single-molecule sensing of peptides and nucleic acids by engineered aerolysin nanopores.Semantic proximity Read ↗

Multiplexed detection of viral antigen and RNA using nanopore sensing and encoded molecular probesSemantic proximity Read ↗

Electroanalysis of single-nucleotide polymorphism by hairpin DNA architectures.Semantic proximity Read ↗

An Introduction to Nanopore Sequencing: Past, Present, and Future ConsiderationsSemantic proximity Read ↗

Single molecule based SNP detection using designed DNA carriers and solid-state nanopores.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.