Article

<i>PTPN11</i> Mutation Clonal Hierarchy in Acute Myeloid Leukemia

2024-09-20

Abstract excerpt

<h4>Summary</h4> Mutations in protein tyrosine phosphatase non-receptor type 11 ( PTPN11 ) have been considered late acquired mutations in acute myeloid leukemia (AML) development. To interrogate the ontogeny of PTPN11 mutations, we utilized single-cell DNA sequencing and identified that PTPN11 mutations can occur as initiating events in some AML patients when accompanied by strong oncogenic drivers, commonly...

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Literature Corpus work: 4b7635d0-bb32-5a72-9f8c-978eff09afea
DOI: 10.1101/2024.09.18.612239

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