Article
Characterization of the clonal hierarchy and immunophenotype of PTPN11 mutations in acute myeloid leukemia.
JCI insight - 23 Feb 2026
Fobare Sydney, Sharpe Chia, Quinn Kate, Bryant Kinsey, Miles Linde A, Bowman Robert L, Cheney Carolyn, Furby Casie, Long Marissa, Fyock Kaytlynn, Wronowski Ben, Lerma James R, Mrózek Krzysztof, Nicolet Deedra, Sesterhenn Thomas M, Johnstone Megan E, Pan Jianmin, Rai Shesh N, Pasare Chandrashekhar, Zimmermann Nives, Yu Wen-Mei, Qu Cheng-Kui, Carroll Andrew, Stone Richard, Wang Eunice S, Kolitz Jonathan, Powell Bayard, Perentesis John P, Eisfeld Ann-Kathrin, Hertlein Erin, Byrd John C
Abstract excerpt
Mutations in protein tyrosine phosphatase non-receptor type 11 (PTPN11) have been considered late acquired mutations in acute myeloid leukemia (AML) development. Using single-cell DNA sequencing, we found that PTPN11 mutations can occur as initiating events in some patients with AML when accompanied by strong oncogenic drivers, commonly NPM1 mutations. The resulting AML has a diverse set of variably...
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