Article

SETBP-1 mutations favor transformation to AML in PTPN-11 positive JMML

2024-07-21

Abstract excerpt

<h4>Background: </h4> Juvenile Myelomonocytic leukemia(JMML) is a rare and aggressive malignancy found in children. The genomic landscape of the JMML shows that the most common mutated genes found in the RAS. The risk stratification and the management of JMML patients is determined by the precise evaluation of the underlying genetic mutations. The co-occurring mutations along with the RAS pathway mutations may aff...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 27e60383-a463-5e16-8144-3bc0b5526cd5
DOI: 10.22541/au.172156205.53527410/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

SETBP-1 mutations favor transformation to AML in PTPN-11 positive JMMLDOI 10.22541/au.172156205.53527410/v1Read

Exome sequencing identifies secondary mutations of SETBP1 and JAK3 in juvenile myelomonocytic leukemia.Semantic proximity Read

Juvenile myelomonocytic leukemia - A bona fide RASopathy syndrome.Semantic proximity Read

SETBP1 mutations as a biomarker for myelodysplasia /myeloproliferative neoplasm overlap syndromeSemantic proximity Read

PTPN11 mutation with additional somatic alteration indicates unfavorable outcome in juvenile myelomonocytic leukemia: a retrospective clinical study from a single center.Semantic proximity Read

Characteristics of RAS pathway mutations in juvenile myelomonocytic leukaemia: a single-institution study from Korea.Semantic proximity Read

Juvenile myelomonocytic leukemia: who’s the driver at the wheel?Semantic proximity Read

After 95 years, it's time to eRASe JMML.Semantic proximity Read

Bedside to bench in juvenile myelomonocytic leukemia: insights into leukemogenesis from a rare pediatric leukemia.Semantic proximity Read

Clinical characteristics and prognostic analysis of acute myeloid leukemia patients with PTPN11 mutations.Semantic proximity Read

The Clinical impact of PTPN11 mutations in adults with acute myeloid leukemia.Semantic proximity Read

SETBP1 mutations occur in 9% of MDS/MPN and in 4% of MPN cases and are strongly associated with atypical CML, monosomy 7, isochromosome i(17)(q10), ASXL1 and CBL mutations.Semantic proximity Read

Subclonal mutations in SETBP1 confer a poor prognosis in juvenile myelomonocytic leukemia.Semantic proximity Read