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The Clinical impact of PTPN11 mutations in adults with acute myeloid leukemia.

Leukemia - 1 Mar 2021

Alfayez Mansour, Issa Ghayas C, Patel Keyur P, Wang Feng, Wang Xuemei, Short Nicholas J, Cortes Jorge E, Kadia Tapan, Ravandi Farhad, Pierce Sherry, Assi Rita, Garcia-Manero Guillermo, DiNardo Courtney D, Daver Naval, Pemmaraju Naveen, Kantarjian Hagop, Borthakur Gautam

Abstract excerpt

While germline and somatic mutations in the gene PTPN11, encoding a phosphatase which regulates the RAS signaling pathway, are well characterized in children with Noonan syndrome and juvenile myelomonocytic leukemia, less is known about their clinical impact in adults with acute myeloid leukemia (AML). To elucidate the effect of PTPN11 mutations (PTPN11mut) on clinical outcomes, we screened adult patients with...

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PMID: 32561839
DOI: 10.1038/s41375-020-0920-z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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