Article

A conserved choreography of mRNAs at centrosomes reveals a localization mechanism involving active polysome transport

2020-09-04

Abstract excerpt

Local translation allows for a spatial control of gene expression. Here, we used high-throughput smFISH to screen centrosomal protein-coding genes, and we describe 8 human mRNAs accumulating at centrosomes. These mRNAs localize at different stages during cell cycle with a remarkable choreography, indicating a finely regulated translational program at centrosomes. Interestingly, drug treatments and reporter analyse...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4b626319-7479-5418-840d-2b017a4fe25e
DOI: 10.1101/2020.09.04.282038

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A conserved choreography of mRNAs at centrosomes reveals a localization mechanism involving active polysome transportDOI 10.1101/2020.09.04.282038Read

A localization screen reveals translation factories and widespread co-translational RNA targetingSemantic proximity Read

Novel ciliary protein TRIM8 is a multifunctional workhorse during mitosisSemantic proximity Read

Neuronal late endosomes serve as selective RNA hubs disrupted by ALS-linked FUS mutationSemantic proximity Read

Spatial and Functional Mapping of Spliceosome and Centrosome Proximity Revealed by Proteogenomics Profiling Semantic proximity Read

Spatially and temporally regulating translation via mRNA ‐binding proteins in cellular and neuronal functionSemantic proximity Read

RNA-binding protein Orb2 causes microcephaly and supports centrosome asymmetry in Drosophila neural stem cellsSemantic proximity Read

The Rab5 effector FERRY links early endosomes with mRNA localizationSemantic proximity Read

RTTN moonlights beyond the centrosome to control ribosome biogenesis and tRNA modification in human brain organoidsSemantic proximity Read

Single-cell quantification of ribosome occupancy in early mouse development.Semantic proximity Read

The centrosome cycleSemantic proximity Read

The novel Rab5 effector FERRY links early endosomes with the translation machinerySemantic proximity Read

Systematic discovery of subcellular RNA patterns in the gut epitheliumSemantic proximity Read