Article

Neuronal late endosomes serve as selective RNA hubs disrupted by ALS-linked FUS mutation

2026-01-20

Abstract excerpt

<h4>ABSTRACT</h4> Neurons depend on tightly regulated positioning of cellular components to maintain long-distance signaling, but the mechanisms guiding specific mRNAs to distant regions remain unclear. Here we show that late endosomes function as selective RNA carriers in human motor neurons and uncover the molecular logic guiding their loading. Using APEX2-mediated proximity labeling, we identify the external t...

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Literature Corpus work: a5b3c01c-e43f-5e7f-ac67-8b68d5b0d816
DOI: 10.64898/2026.01.19.700337

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