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The Rab5 effector FERRY links early endosomes with mRNA localization

1 Jun 2023

Abstract excerpt

Localized translation is vital to polarized cells and requires precise and robust distribution of different mRNAs and ribosomes across the cell. However, the underlying molecular mechanisms are poorly understood and important players are lacking. Here, we discovered a Rab5 effector, the five-subunit endosomal Rab5 and RNA/ribosome intermediary (FERRY) complex, that recruits mRNAs and ribosomes to early endosomes...

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Identifiers

PMID: 37267905
DOI: 10.1016/j.molcel.2023.05.012

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