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RNA-binding protein Orb2 causes microcephaly and supports centrosome asymmetry in <i>Drosophila</i> neural stem cells

2021-11-23

Abstract excerpt

To maintain a balance of self-renewal versus neurogenesis, neural stem cells (NSCs) undergo asymmetric cell division along an invariant polarity axis instructed by centrosomes. In the NSCs of the third instar Drosophila larval brain, the interphase centrosomes are defined by marked asymmetries in protein composition and functional activity as microtubule-organizing centers. Here we show that a conserved RNA-bindi...

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Literature Corpus work
8f47e9d3-4c53-5774-8d2d-fbf2b76e5cbc
DOI
10.1101/2021.11.23.469707
Open publication

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RNA-binding protein Orb2 causes microcephaly and supports centrosome asymmetry in <i>Drosophila</i> neural stem cellsDOI 10.1101/2021.11.23.469707
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