Systematic discovery of subcellular RNA patterns in the gut epithelium

Abstract excerpt

BACKGROUND: Subcellular RNA localization is crucial for the spatio-temporal control of protein synthesis and underlies key processes during development, homeostasis, and disease. In epithelial cells, RNA can localize asymmetrically along the apico-basal axis. Yet, the localization of most transcripts as well as the diversity of patterns that they adopt remains unexplored. RESULTS: Here, we use APEX-seq for...

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