Novel ciliary protein TRIM8 is a multifunctional workhorse during mitosis

Abstract excerpt

<h4>ABSTRACT</h4> TRIM8 is an E3 ubiquitin ligase that functions as both a tumour suppressor and an oncoprotein. Earlier, we reported that TRIM8 interacts with key regulators of mitotic spindle assembly, and that TRIM8 knockdown results in mitotic delay and aneuploidy. In this study, we implemented a multi-omics strategy with differential transcriptomic (single-cell RNA sequencing or scRNA-seq), translatomic (pol...

Topics

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• Cancer Mechanisms and Therapy
• Cytokine Signaling Pathways and Interactions
• interferon and immune responses
• Microtubule and mitosis dynamics
• Neuroblastoma Research and Treatments
• Ocular Diseases and Behçet’s Syndrome
• Toxoplasma gondii Research Studies
• Ubiquitin and proteasome pathways

Identifiers and source

Literature Corpus work

68496601-bcb5-5a2b-a453-a239bb84a9ae

DOI

10.1101/2025.03.28.646005