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Article

Single-cell quantification of ribosome occupancy in early mouse development.

Nature - 1 Jun 2023

Ozadam Hakan, Tonn Tori, Han Crystal M, Segura Alia, Hoskins Ian, Rao Shilpa, Ghatpande Vighnesh, Tran Duc, Catoe David, Salit Marc, Cenik Can

Abstract excerpt

Translation regulation is critical for early mammalian embryonic development1. However, previous studies had been restricted to bulk measurements2, precluding precise determination of translation regulation including allele-specific analyses. Here, to address this challenge, we developed a novel microfluidic isotachophoresis (ITP) approach, named RIBOsome profiling via ITP (Ribo-ITP), and characterized...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 37344592
DOI: 10.1038/s41586-023-06228-9
PMCID: PMC10307641

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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