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RTTN moonlights beyond the centrosome to control ribosome biogenesis and tRNA modification in human brain organoids

2026-08-18

Abstract excerpt

RTTN (rotatin) is a centrosomal protein mutated in severe malformations of cortical development, yet how its dysfunction disrupts human corticogenesis has remained unclear. Here, we show that RTTN has an unrecognized function at the core of the translation machinery. Using human telencephalic and hippocampal organoids carrying distinct RTTN alleles, together with single-cell and bulk transcriptomics, polysome pro...

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Literature Corpus work
41f6a5a4-5f13-5e21-84b1-673e8cfded90
DOI
10.64898/2026.08.13.744412
Open publication

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RTTN moonlights beyond the centrosome to control ribosome biogenesis and tRNA modification in human brain organoidsDOI 10.64898/2026.08.13.744412
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