Article

Selective inhibition of human translation by a drug-like compound that traps terminated protein nascent chains on the ribosome

2020-05-22

Abstract excerpt

Methods to directly inhibit gene expression using small molecules hold promise for the development of new therapeutics targeting proteins that have evaded previous attempts at drug discovery. Among these, small molecules including the drug-like compound PF-06446846 (PF846) selectively inhibit the synthesis of specific proteins, by stalling translation elongation 1–4 . These molecules also inhibit translation term...

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Literature Corpus work: 4b510234-75c7-5d26-85d0-27fbfd33b004
DOI: 10.1101/2020.05.20.106807

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