Article

Engineered transfer RNAs for suppression of premature termination codons

2018-08-27

Abstract excerpt

<h4>ABSTRACT</h4> Premature termination codons (PTCs) are responsible for 10-15% of all inherited disease. PTC suppression during translation offers a promising approach to treat a variety of genetic disorders, yet small molecules that promote PTC read-through have yielded mixed performance in clinical trials. We present a high-throughput, cell-based assay to identify a nti c odon e ngineered transfer RNAs (AC...

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Literature Corpus work: 45cd9cf0-3988-5a7e-9a5c-d86a0763dd1e
DOI: 10.1101/400127

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