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Article

Therapeutic suppression of premature termination codons: mechanisms and clinical considerations (review).

International journal of molecular medicine - 1 Aug 2014

Karijolich John, Yu Yi-Tao

Abstract excerpt

An estimated one-third of genetic disorders are the result of mutations that generate premature termination codons (PTCs) within protein coding genes. These disorders are phenotypically diverse and consist of diseases that affect both young and old individuals. Various small molecules have been identified that are capable of modulating the efficiency of translation termination, including select antibiotics of the...

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Identifiers

PMID: 24939317
DOI: 10.3892/ijmm.2014.1809
PMCID: PMC4094583

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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