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Article

A small molecule that induces translational readthrough of CFTR nonsense mutations by eRF1 depletion

16 Jul 2021

Abstract excerpt

Premature termination codons (PTCs) prevent translation of a full-length protein and trigger nonsense-mediated mRNA decay (NMD). Nonsense suppression (also termed readthrough) therapy restores protein function by selectively suppressing translation termination at PTCs. Poor efficacy of current readthrough agents prompted us to search for better compounds. An NMD-sensitive NanoLuc readthrough reporter was used to...

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PMID: 34272367
DOI: 10.1038/s41467-021-24575-x

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