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SARS-CoV-2 Nsp1 binds ribosomal mRNA channel to inhibit translation

2020-07-07

Abstract excerpt

The non-structural protein 1 (Nsp1), also referred to as the host shutoff factor, is the first viral protein that is synthesized in SARS-CoV-2 infected human cells to suppress host innate immune functions 1,2 . By combining cryo-electron microscopy and biochemical experiments, we show that SARS-CoV-2 Nsp1 binds to the human 40S subunit in ribosomal complexes including the 43S pre-initiation complex. The protein i...

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Literature Corpus work
daf69c4f-202a-53f8-ab50-e1d4e727f46a
DOI
10.1101/2020.07.07.191676
Open publication

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SARS-CoV-2 Nsp1 binds ribosomal mRNA channel to inhibit translationDOI 10.1101/2020.07.07.191676
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