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Article

Selectivity of stop codon recognition in translation termination is modulated by multiple conformations of GTS loop in eRF1.

Nucleic acids research - 1 Jul 2012

Wong Leo E, Li Yan, Pillay Shubhadra, Frolova Ludmila, Pervushin Konstantin

Abstract excerpt

Translation termination in eukaryotes is catalyzed by two release factors eRF1 and eRF3 in a cooperative manner. The precise mechanism of stop codon discrimination by eRF1 remains obscure, hindering drug development targeting aberrations at translation termination. By solving the solution structures of the wild-type N-domain of human eRF1 exhibited omnipotent specificity, i.e. recognition of all three stop...

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Identifiers

PMID: 22383581
DOI: 10.1093/nar/gks192
PMCID: PMC3384315

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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