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Article

SARS-CoV-2 Nsp1 binds the ribosomal mRNA channel to inhibit translation.

Nature structural & molecular biology - 1 Oct 2020

Schubert Katharina, Karousis Evangelos D, Jomaa Ahmad, Scaiola Alain, Echeverria Blanca, Gurzeler Lukas-Adrian, Leibundgut Marc, Thiel Volker, Mühlemann Oliver, Ban Nenad

Abstract excerpt

The SARS-CoV-2 non-structural protein 1 (Nsp1), also referred to as the host shutoff factor, suppresses host innate immune functions. By combining cryo-electron microscopy and biochemistry, we show that SARS-CoV-2 Nsp1 binds to the human 40S subunit in ribosomal complexes, including the 43S pre-initiation complex and the non-translating 80S ribosome. The protein inserts its C-terminal domain into the mRNA...

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PMID: 32908316
DOI: 10.1038/s41594-020-0511-8

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