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Single-nucleus RNA-seq2 reveals functional crosstalk between liver zonation and ploidy

12 Jul 2021

Abstract excerpt

Single-cell RNA-seq reveals the role of pathogenic cell populations in development and progression of chronic diseases. In order to expand our knowledge on cellular heterogeneity, we have developed a single-nucleus RNA-seq2 method tailored for the comprehensive analysis of the nuclear transcriptome from frozen tissues, allowing the dissection of all cell types present in the liver, regardless of cell size or...

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PMID: 34253736
DOI: 10.1038/s41467-021-24543-5

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