Article

Atherosclerosis destabilizes regulatory T cells (Tregs) resulting in multiple families of exTregs

2026-07-28

Abstract excerpt

How regulatory T cells (Tregs) lose lineage identity during chronic inflammation remains poorly understood. Here, using inducible Foxp3 lineage tracing together with single-cell transcriptomic, proteomic and T cell receptor (TCR) profiling in atherosclerosis-prone mice, we identify Treg destabilization as a staged and branching differentiation process rather than an abrupt loss of lineage identity. Conventional Tr...

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Literature Corpus work: 4b4c8a9c-0656-53a8-9506-08488e19b26c
DOI: 10.64898/2026.07.25.740705

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