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Adipose-tissue regulatory T cells are a consortium of subtypes that evolves with age and diet

16 Jan 2024

Abstract excerpt

Foxp3 + CD4 + regulatory T (Treg) cells found within tissues regulate local immunity, inflammation, and homeostasis. Tregs in epididymal visceral adipose tissue (eVAT) are critical regulators of local and systemic inflammation and metabolism. During aging and under obesogenic conditions, eVAT Tregs undergo transcriptional and phenotypic changes and are important for containing inflammation and normalizing...

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PMID: 38227656
DOI: 10.1073/pnas.2320602121

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