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Functional Genomics of Brain Aging and Alzheimers Disease: Focus on Selective Neuronal Vulnerability

16 Nov 2010

Abstract excerpt

Pivotal brain functions, such as neurotransmission, cognition, and memory, decline with advancing age and, especially, in neurodegenerative conditions associated with aging, such as Alzheimers disease (AD). Yet, deterioration in structure and function of the nervous system during aging or in AD is not uniform throughout the brain. Selective neuronal vulnerability (SNV) is a general but sometimes overlooked...

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PMID: 21629439
DOI: 10.2174/138920210793360943

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