Article

Inhibiting toxicity of ALS-linked dipeptide repeat proteins by polystyrene sulfonate (PSS)

2023-05-20

Abstract excerpt

The GGGGCC (G4C2) expansion in the noncoding region of C9orf72 is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The repeat region is translated into five different dipeptide repeat proteins (DPRs), of which the arginine-rich DPRs (R-DPRs) poly- GR (GRn) and poly-PR (PRn) are highly neurotoxic. In this study, we characterized the protective effect against R-...

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Literature Corpus work: 59532a0a-4fa1-5d3d-82e8-dcc9d34d21c2
DOI: 10.1101/2023.05.19.541518

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