Article

C9ORF72-derived polyGR polypeptides disrupt passive nucleocytoplasmic transport by tuning protein affinity for the nuclear pore barrier

2026-03-17

Abstract excerpt

Nucleocytoplasmic partitioning is an essential determinant of eukaryotic cellular function, governed by the nuclear pore complex, a molecular portal filled by a disordered phenylalanine-glycine (FG)-rich phase that governs selective entry and exit. Disruption of nucleocytoplasmic partitioning is seen across many different diseases, including viral infection, cancer, and neurodegeneration. However, what determines...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0e20fca0-5bdb-56d6-be91-649d29f50d2b
DOI: 10.64898/2026.03.16.711670

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

C9ORF72-derived polyGR polypeptides disrupt passive nucleocytoplasmic transport by tuning protein affinity for the nuclear pore barrierDOI 10.64898/2026.03.16.711670Read

Novel single molecule imaging approaches reveal structure-function alterations to the nuclear pore complex in early <i>C9ORF72</i> -associated TDP-43 proteinopathySemantic proximity Read

Nup62 is recruited to pathological condensates and promotes TDP-43 insolubility in C9orf72 and sporadic ALS/FTLD.Semantic proximity Read

C9orf72-linked arginine-rich dipeptide repeats aggravate pathological phase separation of G3BP1Semantic proximity Read

Arginine-rich dipeptide-repeat proteins as phase disruptors in C9-ALS/FTDSemantic proximity Read

Toxic PR poly-dipeptides encoded by the <i>C9orf72</i> repeat expansion target Kapβ2 and dysregulate phase separation of low-complexity domainsSemantic proximity Read

C9orf72 dipeptides disrupt the nucleocytoplasmic transport machinery and cause TDP-43 mislocalisation to the cytoplasmSemantic proximity Read

Phase separation of toxic dipeptide repeat proteins related to C9orf72 ALS/FTDSemantic proximity Read

Polyglutamine aggregation in Huntington and related diseases.Semantic proximity Read

Altered Phase Separation and Cellular Impact in C9orf72-Linked ALS/FTDSemantic proximity Read

Parkinson's disease-specific α-Synuclein variants potentially drive Lewy body formation by engaging in promiscuous and non-functional interactions.Semantic proximity Read

HSC70 prevents TDP-43 nuclear puncta formation and toxicity in a novel nuclear puncta cell model for ALSSemantic proximity Read

Proximity proteomics of C9orf72 dipeptide repeat proteins identifies molecular chaperones as modifiers of poly-GA aggregationSemantic proximity Read