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Article

Multi-scale in silico analysis of the phase separation behavior of FUS mutants.

Journal of materials chemistry. B - 11 Dec 2024

Fernando Kalindu S, Chau Ying

Abstract excerpt

Fused in sarcoma (FUS) is an intrinsically disordered RNA-binding protein that helps to regulate transcription and RNA transport while reversibly assembling into membraneless organelles (MLOs). Some mutations of FUS can promote irreversible aggregation, contributing to neurodegenerative diseases. We previously reported a multi-scale computational framework combining a series of molecular dynamics simulations (MD)...

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Identifiers

PMID: 39495179
DOI: 10.1039/d4tb01512f

Genes

FUS
DAP

Variants

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