Article

Modulating populational variance of methyl-guanine methyl transferase expression through miR-181d degradation: a novel mechanism of temozolomide resistance

2025-04-26

Abstract excerpt

Intratumoral heterogeneity plays a pivotal role in cancer evolution, providing the substrate for adaptation to selective pressures, including treatment with chemotherapy. Here, we show that micro-RNA regulation of variance in the expression of the DNA repair protein methyl-guanine methyl transferase (MGMT) contributes to this heterogeneity and acquired therapeutic resistance. In cell lines derived from glioblastom...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4b17b4f1-60f3-50d9-925f-b136f077a88c
DOI: 10.1101/2025.04.22.650094

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Modulating populational variance of methyl-guanine methyl transferase expression through miR-181d degradation: a novel mechanism of temozolomide resistanceDOI 10.1101/2025.04.22.650094Read

Identification of inter- and intra-tumoral molecular phenotypes steering temozolomide resistance in patient-derived glioblastoma cellsSemantic proximity Read

Genomic Exploration of Distinct Molecular Phenotypes Steering Temozolomide Resistance Development in Patient-Derived Glioblastoma Cells.Semantic proximity Read

Ribonucleotide reductase regulatory subunit M2 drives glioblastoma TMZ resistance through modulation of dNTP productionSemantic proximity Read

<i>N</i> <sup>6</sup> -methyladenosine promotes temozolomide resistance through mRNA stabilization in glioblastoma cellsSemantic proximity Read

DNA methylation remodeling in temozolomide resistant recurrent glioblastoma: comparing epigenetic dynamics in vitro and in vivoSemantic proximity Read

miR-181d: a predictive glioblastoma biomarker that downregulates MGMT expressionSemantic proximity Read

Ribonucleotide Reductase Regulatory Subunit M2 as a Driver of Glioblastoma TMZ-Resistance through Modulation of dNTP ProductionSemantic proximity Read

PARP Inhibitor Counteracts Temozolomide Resistance in Glioblastoma MultiformeSemantic proximity Read

Temozolomide in the Era of Precision MedicineSemantic proximity Read

Distinct molecular mechanisms of acquired resistance to temozolomide in glioblastoma cellsSemantic proximity Read

Mitigating temozolomide resistance in glioblastoma via DNA damage-repair inhibitionSemantic proximity Read

Radiation-induced extracellular vesicle (EV) release of miR-603 promotes IGF1-mediated stem cell state in glioblastomasSemantic proximity Read