Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

miR-181d: a predictive glioblastoma biomarker that downregulates MGMT expression

8 May 2012

Abstract excerpt

Genome-wide microRNA (miRNA) profiling of 82 glioblastomas demonstrated that miR-181d was inversely associated with patient overall survival after correcting for age, Karnofsky performance status, extent of resection, and temozolomide (TMZ) treatment. This association was validated using the Cancer Genome Atlas (TCGA) dataset (n= 424) and an independent cohort (n= 35). In these independent cohorts, an association...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related molecular mechanisms research
Share to Glioma Diagnosis and Treatment
Share to MicroRNA in disease regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22570426
DOI: 10.1093/neuonc/nos089

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

miR-181d: a predictive glioblastoma biomarker that downregulates MGMT expressionPMID 22570426Read ↗

miRNA array screening reveals cooperative MGMT-regulation between miR-181d-5p and miR-409-3p in glioblastomaSemantic proximity Read ↗

miR-181d/MALT1 regulatory axis attenuates mesenchymal phenotype through NF-κB pathways in glioblastoma.Semantic proximity Read ↗

Upregulation of miR-125b, miR-181d, and miR-221 Predicts Poor Prognosis in MGMT Promoter-Unmethylated Glioblastoma PatientsSemantic proximity Read ↗

The Role of miRNA for the Treatment of MGMT Unmethylated Glioblastoma MultiformeSemantic proximity Read ↗

Modulating populational variance of methyl-guanine methyl transferase expression through miR-181d degradation: a novel mechanism of temozolomide resistanceSemantic proximity Read ↗

Relevance of circulating MiRNA-21 and MiRNA-181 in prediction of glioblastoma multiforme prognosisSemantic proximity Read ↗

MiR-181b sensitizes glioma cells to teniposide by targeting MDM2Semantic proximity Read ↗

Up-regulation of miR-370-3p restores glioblastoma multiforme sensitivity to temozolomide by influencing MGMT expressionSemantic proximity Read ↗

miR-181b modulates glioma cell sensitivity to temozolomide by targeting MEK1Semantic proximity Read ↗

MiR-181d acts as a tumor suppressor in glioma by targeting K-ras and Bcl-2Semantic proximity Read ↗

miR-130a can predict response to temozolomide in patients with glioblastoma multiforme, independently of O6-methylguanine-DNA methyltransferaseSemantic proximity Read ↗

MiRNA-181d Expression Correlates in Tumor versus Plasma of Glioblastoma Patients—the Base of a Preoperative Stratification Tool for Local Carmustine Wafer UseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.