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Mitigating temozolomide resistance in glioblastoma via DNA damage-repair inhibition

1 Jan 2020

Abstract excerpt

-glycosylase (APNG) and methylguanine-DNA-methyltransferase (MGMT) efficiently mediate the repair of DNA damage caused by temozolomide, reducing treatment efficacy. Consequently, APNG and MGMT inhibition has been proposed as a way of overcoming chemotherapy resistance. Here, we develop a mechanistic mathematical model that explicitly incorporates the effects of chemotherapy on tumour cells, including the...

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PMID: 31964274
DOI: 10.1098/rsif.2019.0722

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