Article

Ribonucleotide Reductase Regulatory Subunit M2 as a Driver of Glioblastoma TMZ-Resistance through Modulation of dNTP Production

2021-11-24

Abstract excerpt

<h4>ABSTRACT</h4> Glioblastoma (GBM) remains one of the most resistant and fatal forms of cancer. Previous studies have examined primary and recurrent GBM tumors, but it is difficult to study tumor evolution during therapy where resistance develops. To investigate this, we performed an in vivo single-cell RNA sequencing screen in a patient-derived xenograft (PDX) model. Primary GBM was modeled by mice treated wi...

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Literature Corpus work: ee4449ea-be95-569e-9412-e65045c754a6
DOI: 10.1101/2021.11.23.469785

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